Seed Grant Recipients 2015-2016

IBACS Seed Grants provide funding for collaborative research projects across the brain and cognitive sciences. Seed Grants also support applications for equipment, research workshops, events, and other activities compatible with the mission of the Institute.

2015-2016 Recipients

Learn about the PIs and projects that received IBACS Seed Grants this year.

Joe LoTurco, Physiology & Neurobiology

Title of Project: A Technology for Imaging Neuron Type Specific Patterns Across Cerebral Cortex

Brain function arises from the distributed activity of many different neuron types, but our current ability to measure the contribution of an entire population of neurons of any particular type is highly limited.  In this project we will capitalize on the expertise of three labs, two in Physiology and Neurobiology and one in Biomedical Engineering, to develop a new approach for measuring the activity of two major classes of neurons, excitatory, neurons and inhibitory neurons, across different brain areas.

Michael O'Neill, Molecular & Cell Biology

Title of Project:Is there a link between Maternal Immunity, X Chromosome Gene Regulation and Autism Spectrum Disorder?

Studies in humans and animal models suggest that offspring born to mothers that have undergone activation of maternal immunity due to viral infection during pregnancy are at increased risk of developing Autism Spectrum Disorder (ASD). A key metabolic pathway, purine synthesis, has been implicated in this immunity-related risk. We are investigating whether a gene on the X chromosome, thought to be important in this pathway, may carry epigenetic mutations leading to the observed increased susceptibility of males to ASD.

Rachel Theodore, Speech, Language & Hearing Sciences

Title of Project: Speech sound processing in bilingual, infant, and impaired populations

The speech signal provides listeners with information about both who is speaking and what is being said. Research on typical adults suggests that efficient comprehension requires integrating these two sources of information. Our project uses behavioral and neuroimaging methods to examine how babies learn to integrate these two sources of information, how bilinguals integrate this information across their two languages,and whether children with language impairment show deficits in integrating talker and linguistic information.

Tammie Spaulding, Speech, Language & Hearing Sciences

Title of Project: Prosody as a window on Specific Language Impairment

Approximately 7% of school-age children meet diagnostic criteria for Specific Language Impairment (SLI): low language ability despite nonlinguistic abilities in the normal range. While there has been little work investigating the neural organization of language in SLI, some previous studies suggest atypical lateralization in SLI: language processing relies heavily on the left hemisphere in children with typical language development, but may be more bilateral in children with SLI. This project tests whether these differences replicate in a larger sample with better controls, and adds an examination of prosody (the melody and rhythm of speech), an aspect of language that typically relies most heavily on the right hemisphere. This project was initiated by a UConn undergraduate student, and brings together an interdisciplinary team from SLHS and Psychological Sciences. The results will form the basis for a grant application to the National Institutes of Health.

Kevin Brown, Biomedical Engineering

Title of Project: Using Network Science to Understand the Organization of Human Lexical Knowledge

Our project aims to shed new light on the organization of human lexical knowledge using graph theory.   We will consider both static and dynamic representations of human phonological and semantic knowledge.  By using cutting-edge graph-theoretic techniques for characterizing the dynamics of functional networks, we will develop new methods for analyzing the behavior and structure of computational models of human word recognition.

R. Holly Fitch, Psychological Sciences

Title of Project: Cognitive task development for mouse neurogenetic models

Research on genetically engineered mouse models is growing rapidly, with particular emphasis on phenotypes that can tie causal genetic mutations/variations to clinical conditions such as autism, depression, schizophrenia, and language disorders. To accomplish this, well-established and "mouse-friendly” tasks (Morris and other mazes, Open Field, novel object, rotarod, and various social paradigms) are often used. The application of engineered mouse models to the study of complex human cognition, however, calls for the development and validation of new tasks that can link to additional aspects of higher-order cognition such as categorization, object-constancy, structural logic, and other forms of rule-learning. A set of 4 new touch-screen operant testing stations recently acquired by the MBNF will be used to develop novel testing programs (via custom software) that can tap such cognitive measures in mice, and thus be used to study genetic modulation of cognition. Once validated, the tasks will seed future behavioral neurogenetic projects for the PIs, as well as others in the field.

Erika Skoe, Speech, Language & Hearing Sciences

Title of Project: Brain Correlates and Early Predictors to School Age Language in Children with Autism Spectrum Disorder

This project investigates the psychological and neurological determinants of language variation in school-age and adolescent children with Autism Spectrum Disorder (ASD). Over the past decade, Naigles and Fein have collected intensive early language data from children with ASD and typically-developing controls. In this follow-up project, now in collaboration with Skoe, the children will be visited again in their homes to obtain neural measurements in the form of auditory brainstem responses.

Gerry Altmann, Psychological Sciences

Title of Project: The role of distinct brain systems during language and event comprehension

Events typically entail change, but an under-studied topic in cognitive psychology concerns how we encode and track the changes that individual objects undergo as events unfold. On hearing “The chef will chop the onion”, we must keep track of multiple versions of the onion; before the chopping, and after. We are using simultaneous fMRI and EEG recording to explore the role of the brain’s memory systems and other structures during the comprehension of such events.

Letitia NaiglesPsychological Sciences

Title of Project: UConn KIDS Community Activities & Outreach

UConn KIDS (Kids in Developmental Science) comprises a consortium of researchers who examine core aspects of typical and atypical child development, including cognition, language, and social relationships.  Participating departments and programs include Cognitive Science, Educational Psychology, Human Development and Family Studies, Linguistics, Psychological Sciences, Speech, Language, and Hearing Sciences, and the Rudd Center. Funding from the Connecticut IBACS helps to support the activities of our Child Research Recruitment Coordinator and the infrastructure of our on-line participant database.